Pharmacological Characterization of 1-(5-Chloro-6-(Trifluoromethoxy)-1H-Benzoimidazol-2-yl)-1H-Pyrazole-4-Carboxylic Acid (JNJ-42041935), A Potent and Selective HIF Prolyl Hydroxylase (PHD) Inhibitor

T.D. Barrett, H.L. Palomino, T.I. Brondstetter, K.C. Kanelakis, X. Wu, P.V. Haug, W. Yan, A. Young, H. Hua, J.C. Hart, D.T. Tran, H. Venkatesan, M.D. Rosen, H.M. Peltier, K. Sepassi, M.C. Rizzolio, S.D. Bembenek, T. Mirzadegan, M.H. Rabinowitz, N.P. Shankley, Mol. Pharmacol. 79, 910 (2011).

Read article…